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Five patients developed a second brain tumour:two had astrocytoma,two meningioma,and one meningeal sarcoma.The cumulative risk of developing a second brain tumour over the first 10 years after treatment was 1.3%(95% confidence interval 0.4%to 3.9%)and over 20 years 1.9%(0.7%to 5.0%).The relative risk of a second brain tumour compared with the incidence in the normal population was 9.38(3.05 to 21.89).There was no excess risk of any other type of second primary malignancy.Conclusions-There is an increased risk of second intracranial tumour in patients with pituitary adenoma treated with surgery and radiotherapy.Although radiation is likely to be the most important factor contributing to the excess risk,further study is required in a cohort of similar patients not receiving radiation. |
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astrocytoma
carcinoma
glioma
meninges
meningioma
neoplasm,pituitary,treatment of
neoplasm,primary intracranial
neoplasm,primary of CNS
neoplasm,second primary
pituitary,adenoma
radiation induced neoplasm
radiation therapy,CNS treatment and complications with
sarcoma
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